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KMID : 0615720150320030117
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Jouranl of Korean Acupuncture and Moxibustion society
2015 Volume.32 No. 3 p.117 ~ p.126
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Stability and Safety of Bee Venom with and without Additives
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Bae Young-Hyeon
Lee Chong-Hwan
Kim Hae-Sol
Kim Ho-Sun
Suh Chang-Yong
Kim No-Hyeon
Lee Jin-Ho
Ha In-Hyuk
Kim Mi-Riong
Chung Hwa-Jin
Lee In-Hee
Kim Min-Jeong
Kim Eun-Ji
Lee Jae-Woong
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Abstract
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Objectives: Previous studies have shown that the amount of melittin, the main active ingredient in bee venom pharmacopuncture, tends to decrease substantially with time during pharmacopuncture manufacture. This study aimed to assess whether the stability of bee venom pharmacopuncture improved with pharmacopuncture additives.
Methods: Components were measured using high performance liquid chromatography. Acute toxicity and antigenicity tests by subcutaneous and venous routes were conducted at Korea Pharmaceutical Test & Research Institute and mortality, adverse reactions, and body weight changes were assessed.
Results: Stability tests using additives revealed that bee venom without additives was most stable. Bee venom pharmacopuncture without additives was further tested for toxicity in subcutaneous and venous administration in mice and no changes pertaining to toxicity were found over the testing period.
Conclusions: Bee venom pharmacopuncture without additives was found to be most stable, and further, it did not show toxicity or antigenicity in subcutaneous and venous administration in mice.
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KEYWORD
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Bee venom, Pharmacopuncture, Melittin
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